Journal: Signal Transduction and Targeted Therapy

Article Title: M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation

doi: 10.1038/s41392-026-02609-4

Figure Lengend Snippet: Overexpression of circArhgap26 ameliorates cardiac ischemic injury. a Schematic diagram of this study. b , c Representative echocardiography images and quantification of EFs and FSs ( n = 6). d Serum LDH levels ( n = 6). e Caspase-3 activity in the heart ( n = 6). f cTnT levels in plasma samples ( n = 6). g Representative TUNEL-stained images of heart sections and quantitative data ( n = 6). h Representative Evans blue/TTC dual-stained heart sections and quantitative data ( n = 6). Scale bar = 1 mm. i The protein levels of Bax ( n = 8) and Bcl2 ( n = 6) were detected via western blotting. The data are expressed as the means ± SEMs. P < 0.05 was considered statistically significant

Article Snippet: The cTnT ELISA kit was obtained from Nanjing Jiancheng Bioengineering Institute (Nanjing, China), and all procedures were performed in accordance with the manufacturer’s instructions.

Techniques: Over Expression, Activity Assay, Clinical Proteomics, TUNEL Assay, Staining, Western Blot